Standardized PSG analysis

The standardized scoring of sleep and associated events on the basis of polysomnography (PSG) is the gold standard in sleep research and in the development of investigational products affecting sleep.

This measurement provides objective information on the duration and structure of sleep ("sleep architecture"), which is revealed exclusively by this method. Different agents (like benzodiazepines, z-drugs, orexin receptor antagonists) show a characteristic profile in sleep architecture.

After over 40 years of standardized sleep scoring, sleep research is still confronted with a lack of objectivity and reliability in polysomnography-based findings. The well-known large inter-rater variability in purely visual scoring limits the usefulness of PSG in clinical trials, increases sample sizes and adds complexity to an already complex instrument. Furthermore, differences in the methods of data acquisition and in the quality of data across investigator sites further impedes on the efficiency of a sleep trial involving PSG.

The Siesta Group is the developer of Somnolyzer 24x7, the world's most reliable and valid tool for computer-assisted sleep scoring. The use of Somnolyzer 24x7 and its related EEG analysis tools in clinical trial ensures a quality of endpoints unsurpassed by other providers in the field.

Extended Sleep-EEG analysis

Complementary to the standardized classification of sleep, the extended analysis if sleep EEG allows for a more detailed investigation of sleep processes and their changes by pharmacological interventions.

These analyses include:

  • Sleep Microstructure analysis
    • Sleep spindles
    • K-complexes
    • EEG arousals
    • Cyclic Alternating Patterns (CAP)
    • REM density and intensity)
  • FFT/Spectral analysis
  • Periodic limb movements and respiratory events
  • EEG Mapping